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KMID : 0829220110350060345
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Korean Journal of Oral and Maxillofacial Pathology
2011 Volume.35 No. 6 p.345 ~ p.357
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Expression of E-cadherin/β-catenin Cell Adhesion Complex in Squamous Cell Carcinoma of Tongue and their Role in Prognosis, Metastasis and Recurrence
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KM Ahsan Kabir
Kim Seo-Yune
Lim Won-Bong
Kim Ji-Sun
Ko Young-Jong
Kim Sang-Woo
Oh Mi-Ra
Oh Hee-Kyun
Choi Hong-Ran
Kim Ok-Joon
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Abstract
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Recurrence-metastasis status of squamous cell carcinoma of tongue is a challenging oncologic problem. This study examined the expression of E-cadherin/β-catenin cell adhesion complex in squamous cell carcinoma of the tongue through an immunohistochemical study. Twenty samples from 15 patients with squamous cell carcinoma of the tongue, who were treated at the Department of Oral and Maxillofacial Surgery, consisted of primary or recurrent tumors along with matched metastatic lymph nodes were retrieved for immunohistochemical staining and grouped based on recurrence-metastasis status.Differences in stain localization were noted in E-cadherin, β?catenin and phospho β?catenin staining between different tumor groups based on the recurrence-metastasis status. The number of phospho β-catenin stain positive cells was found to have a significant role in survival. E-cadherin confirms its role as a powerful individual differentiation indicator and the role of β-catenin specially the phospho type elicts interest.
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KEYWORD
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β-catenin phospho, β?catenin metastasis, E-cadherin, Squamous cell carcinoma
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